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2 edition of Cardiovascular alterations in a strain of spontaneously diabetic bio-breeding rats. found in the catalog.

Cardiovascular alterations in a strain of spontaneously diabetic bio-breeding rats.

William Durante

Cardiovascular alterations in a strain of spontaneously diabetic bio-breeding rats.

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Published .
Written in English


The Physical Object
Pagination165 leaves
Number of Pages165
ID Numbers
Open LibraryOL15409270M


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Cardiovascular alterations in a strain of spontaneously diabetic bio-breeding rats. by William Durante Download PDF EPUB FB2

Cardiac dysfunction in isolated perfused hearts from spontaneously diabetic BB rats Article (PDF Available) in Canadian Journal of Physiology and Pharmacology 68(4). Rodent models for T2DM include except ZDF rats also Goto-Kakizaki (GK) rats, Otsuka Long-Evans Tokushima Fatty (OLETF) rats, spontaneously diabetic Tori (SDT) rats, Kuo Kondo (KK) mice, ob/ob+/+ mice, and db/db+/+ mice.

GK rats are nonobese Wistar substrain which develops T2DM early. Male OLETS rats suffer from diabetes at 18–25 weeks of : Marcela Capcarova, Anna Kalafova. The study of diabetic neuropathy has relied primarily on the use of streptozotocin-treated rat and mouse models of type 1 diabetes.

This chapter will review the creation and use of other rodent Author: Mark A Yorek. The most frequently used animal models are rats or mice with T1DM induced by β-cell-destroying drugs, alloxan or—in the large majority of studies—streptozotocin (STZ), and BB (Bio-Breeding) rats with spontaneous immune-mediated diabetes.

Although T1DM can be drug induced at any age, BB rats develop diabetes past the peak growth rate (7 weeks).Author: Caterina Conte, Roger Bouillon, Nicola Napoli. The ZDF rat is characterized by development of diabetes between 7 and 12 weeks of age.

As shown in Figurenon-fasting plasma glucose levels of to mg/dL are seen at 8 weeks, and levels of to mg/dL are seen at 12 weeks in the obese male rat fed a diet of Purina Rodent LabDiet (PMI Nutrition, Richmond, IN).

Download: Download full-size Cited by: 7. The Zucker fatty/Spontaneously hypertensive heart failure F1 hybrid (ZSF1) rat, a spontaneous diabetic model with hypertension and obesity which is commonly used as a DN model, are bred by crossing lean female Zucker diabetic fatty (ZDF) rats with lean male spontaneously hypertensive heart failure rats (SHHRs), thus creating a model with many Author: Inês Preguiça, André Alves, Sara Nunes, Pedro Gomes, Rosa Fernandes, Sofia D.

Viana, Flávio Reis. Animal models remain essential to understand the fundamental mechanisms occurring in fetal medicine and obstetric diseases, such as intrauterine growth restriction, preeclampsia and gestational diabetes.

These vary regarding the employed method used for induction of the disease, and differ in relation to the animal characteristics (size, number of fetuses, placenta Cited by: 4. BB rats spontaneously develop diabetes at an early age as is the case in NOD mice and humans.

BB/Wor rats (U. of Massachusetts Medical School, Worchester Mass., USA) were immunized with a combination of the anthrax and DTP vaccines (n=20) or nothing as a control (n=28). Groups contained approximately equal number of male and female rats. Abstract. Pain is frequently the earliest and most problematic syndrome of distal peripheral neuropathy (DPN) in diabetic patients.

The variety of time of onset, duration and progression, modalities, and severity of individual presentations of painful DPN makes classification and evaluation of mechanisms of pain in patients with diabetic neuropathy an Cited by: I: Studies in ob/ob and db/db mice, diabetic Chinese hamsters, and normal and streptozotocin-diabetic rats.

Diabetes – Google Scholar Ciaraldi TP, Gilmore A, Olefsky JM, Goldberg M, Heidenreich KA () In vitro studies on the action of CS, a new antidiabetic agent. Immu‐ nohistochemistry was positive in 9 out of 12 (75%) of diabetic patients but only in 10% (1/10) of control subjects (p = ): the protein VP1 was mainly localized in the epithelium.

Viral RNA was found by RT-PCR in a frozen sample from one of the 4 diabetic patients who were 44 Type 1 Diabetes. It was found early that potent ARI sorbinil was effective in preventing cataractous changes in diabetic rats. Diabetic rats treated with sorbinil showed no lens changes during the 5- month period of the experiment.

In contrast untreated diabetic rats developed early lens changes by 3 weeks and dense nuclear opacities by 6 to 9 weeks Full text of "Chemoreception [electronic resource]: from cellular signaling to functional plasticity" See other formats.

Essential Clinical Immunology begins with the basic concepts and then details the immunological aspects of various disease states involving major organs of the body. The book explores how we can better understand disease and its treatment through clinical immunology. Looking forward, each chapter concludes with patterns for future research.

Non-obese diabetic (NOD) mice or Bio Breeding (BB) rats can be used to screen an agent for effectiveness in preventing diabetes.

Mice can be injected as above and blood drawn to check for hyperglycemia at monthly intervals through the first 6 months of life.

B1 () Isocarbohydric substitution of sucrose for wheat starch in the diets of gestatio nal diabetic women Isocarbohydric Isolation and characterization of autoreactive regulatory Th2-like cells from an unprimed female nonobese diabetic (NOD) mouse autoreactive ifile-it LEARNED HELPLESSNESS, DEPRESSION AND THEIR RELATIONSHIP TO ADHERENCE AND.

This important reference, edited by Ronald Ross Watson and Betsy Dokken, collects the research needed to make the distinct connection between pre-diabetes, diabetes, and cardiovascular disease. Glucose Intake and Utilization in Pre-Diabetes and Diabetes: Implications for Cardiovascular Disease explains the mechanisms of progression from pre-diabetes to diabetes to cardiovascular.

For Diabetic Neuropathy: Clinical Management, Second Edition, we have made every effort to reflect the above changes. We have included new chapters that focus more detail on the pathophysiology of the disease, and we have also expanded the sections regarding the diagnosis and the management of the various presentations of diabetic neuropathy.

Foreword Kathryn Bayne, M.S., Ph.D., DV.M., DACLAM, CAAB President, American College of Laboratory Animal Medicine It is estimated that between 90–95% of the animals used in biomedical research are mice and rats; thus, the role that they serve in advancing both human and animal health is vital.

Biotechnology for Sustainability Achievements, Challenges and Perspectives Subhash Bhore, K. Marimuthu & M. Ravichandran (Editors) Published by AIMST University ISBN: (Print version) eISBN: (e-Book version) 2.

This banner text can have markup. web; books; video; audio; software; images; Toggle navigation. Publishing Process Manager Oliver Kurelic Typesetting InTech Prepress, Novi Sad Cover InTech Design Team First published January, Printed in Croatia A free online edition of this book is available at Additional hard copies can be obtained from [email protected] Diabetes Mellitus – Insights and Perspectives, Edited.

Mycophenolate mofetil after methotrexate failure or intolerance in the treatment of scleritis and uveitis. PubMed.

Sobrin, Lucia; Christen, William; Foster, C Stephen. [Relative bioavailability study of two oral formulations of mycophenolate mofetil in healthy volunteers].

PubMed. Saavedra S, Iván; Sasso A, Jaime; Quiñones S, Luis; Saavedra B.